Jonathan C. Trent, MD, PhD

Jonathan C. Trent, MD, PhD, is professor of medicine, associate director for clinical research, and director of the Bone and Soft-tissue Sarcoma Group at the Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, FL. He earned his undergraduate degree in chemistry at Southeastern Oklahoma State University and his MD and PhD in cancer biology from The University of Texas Health Science Center. He completed an internship and residency in internal medicine at The University of Texas Health Science Center and a fellowship in medical oncology at The University of Texas MD Anderson Cancer Center while serving as chief fellow. Prior to joining the University of Miami Miller, he held appointments as faculty of The University of Texas Graduate School of Biomedical Sciences at Houston and associate professor of medicine in the Department of Sarcoma Medical Oncology, Division of Cancer Medicine, at The University of Texas MD Anderson Cancer Center in Houston.

Dr Trent’s interests include the clinical and translational research of sarcomas, the direct care of patients with sarcoma, and education about sarcoma and patient-oriented research. As associate director for clinical research, his goal is to help Sylvester faculty develop clinical trials that provide clinically effective and scientifically exciting therapy to patients with cancer in South Florida and beyond. The major focus of his clinical, educational, and research efforts are with gastrointestinal stromal tumors (GIST), chondrosarcoma, and other sarcomas. The major efforts of Dr Trent’s research focus on understanding the mechanisms of action and resistance of imatinib in GIST and other sarcomas while striving toward improved therapeutic options. His work involves the use of novel preoperative/postoperative clinical trials, prospectively acquired tumor tissue, cell lines, and archival tissue, as well as collaborations with disciplines such as the genomics facility, surgical oncology, pathology, radiology, and interventional radiology.